WINGLESS SIGNALLING ALTERS THE LEVELS, SUBCELLULAR DISTRIBUTION AND DYNAMICS OF ARMADILLO AND E-CADHERIN IN THIRD INSTAR LARVAL WING IMAGINAL DISCS.

Wingless signalling alters the levels, subcellular distribution and dynamics of Armadillo and E-cadherin in third instar larval wing imaginal discs.

BACKGROUND:Armadillo, the Drosophila orthologue of vertebrate ss-catenin, plays a dual role as the key effector of Wingless/Wnt1 signalling, and as a bridge between E-Cadherin and the actin cytoskeleton.In the absence of ligand, Armadillo is phosphorylated and targeted to the proteasome.Upon binding of Wg to its receptors, the "degradation complex"

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RAB11-Mediated Trafficking and Human Cancers: An Updated Review

Many disorders block and subvert basic cellular processes in order to boost their progression.One protein family that is prone to be altered in human cancers is the small GTPase RAB11 family, the master regulator of vesicular trafficking.RAB11 isoforms function as membrane organizers connecting the transport of cargoes towards the plasma membrane w

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Class III Malocclusion Surgical-Orthodontic Treatment

The aim of the present case report is to describe the orthodontic-surgical treatment of a 17-year-and-9-month-old female patient with a Class III malocclusion, poor facial esthetics, and mandibular and chin protrusion.She had significant anteroposterior and transverse discrepancies, a concave profile, and strained lip closure.Intraorally, she had a

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