Wingless signalling alters the levels, subcellular distribution and dynamics of Armadillo and E-cadherin in third instar larval wing imaginal discs.
BACKGROUND:Armadillo, the Drosophila orthologue of vertebrate ss-catenin, plays a dual role as the key effector of Wingless/Wnt1 signalling, and as a bridge between E-Cadherin and the actin cytoskeleton.In the absence of ligand, Armadillo is phosphorylated and targeted to the proteasome.Upon binding of Wg to its receptors, the "degradation complex"